908865-11-2Relevant academic research and scientific papers
Novel potent and?selective αvβ3αvβ5 integrin dual antagonists with reduced binding affinity for?human serum albumin
Raboisson, Pierre,Manthey, Carl L.,Chaikin, Margery,Lattanze, Jennifer,Crysler, Carl,Leonard, Kristi,Pan, Wenxi,Tomczuk, Bruce E.,Marugán, Juan José
, p. 847 - 861 (2007/10/03)
The binding of lead compounds and drugs to human serum albumin (HSA) is a ubiquitous problem in drug discovery since it modulates the availability of the leads and drugs to their intended target, which is linked to biological efficacy. In our continuing e
