90888-01-0Relevant academic research and scientific papers
Kinetic resolution of iodophenylethanols by Candida antarctica lipase and their application for the synthesis of chiral biphenyl compounds
Rocha, Lenilson C.,Rosset, Isac G.,Luiz, Rodrigo F.,Raminelli, Cristiano,Porto, Andre L.M.
experimental part, p. 926 - 929 (2010/08/07)
The kinetic resolution of (±)-iodophenylethanols was carried out using lipase from Candida antarctica and in some cases the enantiomeric excesses were high (up to >98%). Enantiomerically enriched (S)-iodophenylethanols produced by the enzymatic resolution process were used in the synthesis of chiral biphenyl compounds by the Suzuki reaction with good yields (63-65%).
