90891-21-7Relevant articles and documents
Catalytic Staudinger Reduction at Room Temperature
Lenstra, Danny C.,Wolf, Joris J.,Mecinovi?, Jasmin
, p. 6536 - 6545 (2019/05/24)
We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.
Asymmetric transfer hydrogenation of β,γ-alkynyl α-lmino esters by a bronsted acid
Kang, Qiang,Zhao, Zhuo-An,You, Shu-Li
scheme or table, p. 2031 - 2034 (2009/04/10)
Asymmetric synthesis of trans-alkenyl α-amino esters was realized by chiral phosphoric acid catalyzed transfer hydrogenatlon of β,γ- alkynyl α-imino esters. Utilizing Hantzsch esters as the hydrogen donor, both the alkyne and Imine moieties of β,γ-alkynyl
Ethyl 2,4-dioxo-4-phenylbutyrate: A versatile intermediate for the large-scale preparation of enantiomerically pure α-hydroxy and α-amino acid esters
Blaser, Hans-Ulrich,Burkhardt, Stephan,Kirner, Hans Juerg,Moessner, Tanja,Studer, Martin
, p. 1679 - 1682 (2007/10/03)
Starting from ethyl 2,4-dioxo-4-phenylbutyrate, both enantiomers of six enantiomerically pure α-hydroxy and α-amino acid esters (homophenylalanine derivatives) were prepared on >100 g scale. The key step involves a Pt-cinchona catalyzed enantioselective hydrogenation followed by enrichment via crystallization. All derivatives are commercially available.