90897-92-0

Basic information

• Product Name: 3,4-DIFLUOROPHENYLMAGNESIUM BROMIDE
• Synonyms: 3,4-DIFLUOROPHENYLMAGNESIUM BROMIDE;3,4-DIFLUOROPHENYLMAGNESIUM BROMIDE, 0.5M SOLUTION IN TETRAHYDROFURAN;3,4-difluorophenylmagnesium bromide solution;3,4-Difluorophenylmagnesium bromide,0.5M solution in THF;3,4-Difluorophenylmagnesium bromide, 0.5M solution in THF, AcroSeal§3;3,4-Difluorophenylmagnesium bromide solution 0.5 in THF;3,4-Difluorophenylmagnesium bromide, 0.5M solution in THF, AcroSeal;3,4-DifluorophenylMagnesiuM broMide, 0.50 M in 2-MeTHF
• CAS NO: 90897-92-0
• Molecular Formula: C₆H₃BrF₂Mg
• Molecular Weight: 217.29
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents
• Mol File: 90897-92-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: 1 °F
• Appearance: Yellow to dark brown/Solution
• Density: 0.965 g/mL at 25 °C
• Storage Temp.: 2-8°C
• Water Solubility: Reacts with water.
• Sensitive: Air & Moisture Sensitive
• CAS DataBase Reference: 3,4-DIFLUOROPHENYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIFLUOROPHENYLMAGNESIUM BROMIDE(90897-92-0)
• EPA Substance Registry System: 3,4-DIFLUOROPHENYLMAGNESIUM BROMIDE(90897-92-0)

Safety Data

• Hazard Codes: F,C,Xn
• Statements: 11-14-19-22-34-40-36/37
• Safety Statements: 16-26-33-36/37/39-45-36/37
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• HazardClass: 3
• Hazardous Substances Data: 90897-92-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 90897-92-0 differently. You can refer to the following data:
1. 3,4-Difluorophenylmagnesium bromide, 0.50 M in 2-MeTHF is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.
2. 3,4-Difluorophenylmagnesium bromide can be used:To prepare 3,4-difluorophenylboronic acid, a key building block employed in the synthesis of norepinephrine transporter selective molecules.In the synthesis of trimethoxybenzophenone derived tubulin polymerization inhibitors.In one of the key synthetic steps for the preparation of diarylketoxime derivatives as potent MCH-1R antagonists.In the synthesis of biologically important hydroxybupropion analogs useful in smoking cessation.

InChI:InChI=1/C6H3F2.BrH.Mg/c7-5-3-1-2-4-6(5)8;;/h1,3-4H;1H;/q;;+1/p-1/rC6H3BrF2Mg/c7-10-4-1-2-5(8)6(9)3-4/h1-3H

Upstream product

• 348-61-8 1-bromo-3,4-difluorobenzene 

Downstream Products

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• 1017598-63-8 (3,4-difluorophenyl)(5-methylpyrazin-2-yl)methanone 
• 1146593-96-5 (3,4-difluorophenyl)cycloheptane 
• 1146594-02-6 1-decyl-3,4-difluorobenzene 
• 1146594-06-0 3,4-difluoro-4'-vinylbiphenyl 
• 189749-71-1 4-(4-bromophenethyl)-1,2-difluorobenzene 
• 1146594-03-7 N-[3-(3,4-difluorophenyl)propyl]indole 
• 951892-54-9 4-(but-3-enyl)-1,2-difluorobenzene 
• 1057672-34-0 4-(3,4-difluorophenyl)butyronitrile 
• 1159628-74-6 tert-butyl 2-(3,4-difluorophenyl)-2-oxoacetate 
• 1192035-82-7 C₁₅H₁₅F₂NO₂ 
• 644982-67-2 1,1-dimethylethyl 4-[1-cyano-2-(ethyloxy)-2-oxoethyl]-4-(3,4-difluorophenyl)-1-piperidinecarboxylate 

Relevant articles and documents

Prodrug of cinnamide compound

The present invention provides a most suitable prodrug of a cinnamide compound. The prodrug is represented by Formula (I) wherein Ra and Rb each denote a C1-6 alkyl group or the like; Xa denotes a methoxy group or a fluorine atom; Y denotes a phosphono group or the like; and A denotes a cyclic lactam derivative.