90901-53-4Relevant academic research and scientific papers
iron(II) Compounds with Isocyanides as Axial Ligands
Hanack, Michael,Thies, Ruediger
, p. 1225 - 1230 (2007/10/02)
Aliphatic and aromatic monodentate isocyanides RNC (R = t-Bu, c-Hx, substituted Ph) react with iron(II) (TPyPFe) to form the corresponding diaxially substituted iron(II) compounds TPyPFe(RNC)2 1a-8a.The spectroscopic data and thermal properties of the complexes are described and compared with the analogous PcFe(CNR)2 compounds 1b-8b.
INDOLE SYNTHESES UTILIZING o-METHYLPHENYL ISOCYANIDES.
Ito,Kobayashi,Seko,Saegusa
, p. 73 - 84 (2007/10/02)
New indole synthesis starting with o-methylphenyl isocyanides such as o-tolyl, 2,4-xylyl, and 2,6-xylyl isocyanide is described. Treatment of o-tolyl isocyanide with LDA in diglyme at minus 78 degree C generated selectively o-(lithiomethyl)phenyl isocyanide in an almost quantitative yield, which on warming up to room temperature was cyclized to indole after aqueous workup. Similarly, 2,4-xylyl and 2,6-xylyl and 2,6-xylyl isocyanides were cyclized to 5-methylindole and 7-methylindole quantitatively. The o-(lithiomethyl)phenyl isocyanides reacted with electrophiles such as alkyl halides and alkylene oxides to give o-alkylphenyl isocyanides, which were cyclized via the lithiation at the orthobenzylic carbon to afford 3-substituted indoles.
