90909-84-5Relevant academic research and scientific papers
A convenient general synthesis of 3-substituted 2H-chromene derivatives
Kaye, Perry T.,Nocanda, Xolani W.
, p. 1318 - 1323 (2007/10/03)
Reactions of 2-hydroxybenzaldehydes and 2-hydroxy-1-naphthaldehydes with various activated alkenes under Baylis-Hillman conditions have been shown to proceed with regioselective cyclisation to afford the corresponding 3-substituted chromene derivatives. In some cases competitive dimerisation of the alkene component was observed, and direct dimerisation in the absence of the aldehyde has been explored.
Reactions of Bifunctional Molecules with Acceptor-Substituted Butadienes
Flitsch, Wilhelm,Lubisch, Wilfried,Rosche, Juergen
, p. 655 - 660 (2007/10/02)
The butadienyl sulfone 1 and the chlorobutenyl sulfone 2 react under six-ring annulation with salicylaldehyde to give 4 and with 1-(cyclohexenyl)piperidine to give 7.Reaction with 2-pyrrolecarbaldehyde yields the 3a-azaazulenes 10a-c together with the vin
On the Reaction of 2-Pyrrolecarbaldehyde with Hetero-substituted Ethenes
Flitsch, Wilhelm,Lubisch, Wilfried
, p. 1424 - 1435 (2007/10/02)
3H-Pyrrolizines 1 have been obtained from reactions of 2-pyrrolecarbaldehyde with ethenylphosphonates 2 and the phosphane oxide 5, respectively, the ratio of products depending on the structure of the educts.On varying the reaction conditions a controlled synthesis of both isomers 1e/f was achieved.Pyrrolizines, formed in a reaction of 2-pyrrolecarbaldehyde with ethenyl phenyl sulfone (3), could not be isolated since the reaction proceeded to give more complex pyrrolizine derivatives and the cyclazine 11.A mechanism is proposed for this multistep reaction.N-Alkylatio n of 2-pyrrolecarbaldehyde with dihaloalkanes has been carried out using phase transfer catalysis.
