909102-89-2Relevant academic research and scientific papers
Design and synthesis of potent, non-peptidic inhibitors of HPTPβ
Amarasinghe, Kande K.D.,Evidokimov, Artem G.,Xu, Kevin,Clark, Cynthia M.,Maier, Matthew B.,Srivastava, Anil,Colson, Anny-Odile,Gerwe, Gina S.,Stake, George E.,Howard, Brian W.,Pokross, Matthew E.,Gray, Jeffrey L.,Peters, Kevin G.
, p. 4252 - 4256 (2006)
The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPβ. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPβ potency.
