90915-18-7

Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole-5-carboxylic acid, 1,2-dimethyl-(9CI) is used as a pharmaceutical compound for its diverse biological activities. The benzimidazole core provides a foundation for anti-cancer, anti-viral, and anti-inflammatory properties, making it a promising candidate for the development of new drugs.
Used in Organic Synthesis:
1H-Benzimidazole-5-carboxylic acid, 1,2-dimethyl-(9CI) is used as a building block in organic synthesis. The carboxylic acid group allows for further chemical reactions and modifications, enabling the creation of new organic compounds with potential applications in various fields.
Further research and testing are necessary to fully understand the potential uses and properties of 1H-Benzimidazole-5-carboxylic acid, 1,2-dimethyl-(9CI), and to explore its applications in different industries.

Upstream product

• 66315-15-9 3-amino-4-(methylamino)benzoic acid 
• 78-39-7 Triethyl orthoacetate 

Downstream Products

• 256936-11-5 1,2-dimethyl-1H-benzo[d]imidazole-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity

The convergent total synthesis of hypermodified epothilone analogs 1 and 2 has been achieved with the stereoselective cyclopropanation of allylic alcohol 17 and ring-closing olefin metathesis with diene 22 as the key steps. In spite of significant structural differences between these analogs and the natural epothilone scaffold, 1 and 2 are potent inducers of tubulin polymerization and inhibit the growth of human cancer cells in vitro with sub-nM IC50 values.

DICARBONYLIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY

Compounds of formula (I), and their pharmaceutically acceptable salts and solvates, wherein X represents -O-, -NH-, -S-, -NHC(=O)- or -NHC(=S)-; R1 represents -H or a hydrocarbon chain; R2 represents -H, alkoxy, amino, a hydrocarbon chain or a radical of a cycle; R3 represents -H, a hydrocarbon chain or a radical of a cycle; R4 represents -H or a hydrocarbon chain; alternatively R3 and R4 form together a cycle; R5 and R6 represent -H or halogen, and R7 represents -H, a hydrocarbon chain or heteroaryl, are useful against bacterial infections in animals, including humans.