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90917-49-0

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90917-49-0 Usage

Uses

3,5-Diiodo-4-hydroxyphenylacetic Acid Ethyl Ester is an intermediate in the preparation of thyroxine (T425601) and it’s derivatives.

Check Digit Verification of cas no

The CAS Registry Mumber 90917-49-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,9,1 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 90917-49:
(7*9)+(6*0)+(5*9)+(4*1)+(3*7)+(2*4)+(1*9)=150
150 % 10 = 0
So 90917-49-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H10I2O3/c1-2-15-9(13)5-6-3-7(11)10(14)8(12)4-6/h3-4,14H,2,5H2,1H3

90917-49-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-(4-hydroxy-3,5-diiodophenyl)acetate

1.2 Other means of identification

Product number -
Other names EINECS 292-689-1

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:90917-49-0 SDS

90917-49-0Relevant articles and documents

Synthesis of thyroxine: Biomimetic studies

Bell, Natalie V.,Bowman, W. Russell,Coe, Paul F.,Turner, Andrew T.,Whybrow, Del

, p. 873 - 883 (2007/10/03)

The biomimetic oxidative coupling of the ethyl ester of N-acetyl-3,5- diiodotyrosine (1) to yield the ethyl ester of N-acetylthyroxine (2) has been investigated. A putative mechanism involving phenolic coupling to yield an intermediate aryloxydienone (7) followed by an E2 elimination for loss of the side chain has been proposed. Oxidative couplings with analogous 4- substituted 3,5-diiodophenols indicate that a number of mechanisms are possible; these include quinone methide intermediates and S(N)2 substitutions in the intermediate aryloxydienones. Rearomatization of the intermediate aryloxydienones is a strong driving force for the loss of the side chains. The results indicate that 3,5-diiodo-4-aryloxydienones are good leaving groups in E2 and S(N)2 mechanisms. The synthetic method provides a facile synthesis of thyroxine analogues from readily available 4-substituted 3,5- diiodophenols. The biomimetic oxidative coupling of the ethyl ester of N-acetyl-3,5-diiodotyrosine (1) to yield the ethyl ester of N-acetylthyroxine (2) has been investigated. A putative mechanism involving phenolic coupling to yield an intermediate aryloxydienone (7) followed by an E2 elimination for loss of the side chain has been proposed. Oxidative couplings with analogous 4-substituted 3,5-diiodophenols indicate that a number of mechanisms are possible; these include quinone methide intermediates and SN2 substitutions in the intermediate aryloxydienones. Rearomatization of the intermediate aryloxydienones is a strong driving force for the loss of the side chains. The results indicate that 3,5-diiodo-4-aryloxydienones are good leaving groups in E2 and SN2 mechanisms. The synthetic method provides a facile synthesis of thyroxine analogues from readily available 4-substituted 3,5-diiodophenols.

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