90919-46-3

Upstream product

• 95-88-5 4-Chlororesorcinol 
• 107-92-6 butyric acid 
• 5131-60-2 4-chloro-1,3-phenylenediamine 
• 108-46-3 recorcinol 
• 4390-92-5 1-(2,4-dihydroxyphenyl)butan-1-one 
• 141-75-3 butyryl chloride 

Downstream Products

• 1392203-22-3 5-chloro-2,4-dihydroxybutyrophenone oxime 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel chromonyl enaminones as α-glucosidase inhibitors

Series of novel chromonyl enaminones 1a–e and 2a–e and 3-alkylated chromones 3a–e were synthesized and evaluated in vitro as α-glucosidase inhibitors as well as antioxidant and antifungal agents. Antifungal activity was tested on strains of Candida albicans. Compounds 2a and 2d–e showed good inhibition of the α-glucosidase enzyme (IC50 = 5.5, 0.9, and 1.5 mM, respectively), their effect being better than that of 1a–e, 3a–e, and acarbose (the standard, IC50 = 7.73 ± 0.9 mM). The structure–activity relationship suggests that the phenyl group at the C-3 position of the chromone ring system and the 4-chlorophenyl group at the enaminone moiety (derivatives 2) increased the inhibition of α-glucosidase. Compounds 2a–e exhibited a slight antioxidant effect, and compounds 3a–e a moderate antifungal activity against C. albicans (IC50 70.5–83.1 μg/mL). Docking studies revealed that compounds 2 interact with the α-glucosidase residues of the binding pocket. Therefore, these chromone derivatives may be considered as potential α-glucosidase inhibitors, as well as antifungal agents against some Candida strains of yeast.

Spectrophotometric determination of manganese by biologically active 5-chloro-2, 4-dihydroxy butyrophenone oxime

5-Chloro-2, 4-Dihydroxy Butyrophenone oxime (CDHBO) has been successfully employed as a reagent for spectrophotometric determination for Mn(II) at pH range 7.0 to 11.0 in chloroform medium. The composition of the complex 1:2 (metal:ligand) has been confirm by job's method for continuous variation, Yoe & jones mole ratio method & slope ratio method. The stability constant of the complex is found to be 3.94107. The dark brown coloured complex obeys Beer's law over the concentration rangei to 10 ppm for Mn(II) ion. The complex has molar absorptivity 6.0 103 mol-1 cm -1.While their sensitivity is 0.009 μg Mn/cm2.Limits of interference due to the presence of foreign ions in the spectrophotometric determination has also been determined. The standard free energy of the complex is 10.442 Kcal/mole at 30°C. The complex is stable for one week, CDHBO has also been found to give quite satisfactory results for Mn(II) present in synthetic mixtures. The antimicrobial activity of CDHBO and Mn-CDHBO complex have also been calculated.