909207-13-2

Upstream product

• 29800-43-9 ethyl α,2-dioxocycloheptaneacetate 
• 500576-41-0 ethyl 5,6,7,8-tetrahydro-4H-cyclohepta[d]isoxazole-3-carboxylate 
• 33230-32-9 5,6,7,8-tetrahydro-4H-cyclohepta[d]isoxazole-3-carboxylic acid 
• 2252-63-3 1-(4-Fluorophenyl)piperazine 

Relevant academic research and scientific papers

Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression

5,6,7,8-Tetrahydro-4H-cyclohepta[d]isoxazole derivatives were synthesized and evaluated as a novel class of inhibitors for α-melanocyte-stimulating hormone (α-MSH) induced melanogenesis in a mouse melanoma B16F10 cell line. Compound 8e (IC50 = 0.67 μM), 8h (IC50 = 1.01 μM) and 9b (IC50 = 0.99 μM) exhibited a potent inhibitory activity approximately 85- to 126-fold greater than kojic acid, a well-known potent inhibitor. A biochemical study indicates that the activity of this series should be displayed via down-regulation of the expression of tyrosinase.