90947-99-2

Usage

Uses

Used in Organic Synthesis:
7-Bromo-1-chloronaphthalene is used as a building block for the synthesis of other functionalized naphthalene derivatives, contributing to the development of various organic compounds.
Used in Pharmaceutical Industry:
7-Bromo-1-chloronaphthalene is used as a precursor in the synthesis of pharmaceuticals, aiding in the creation of new drugs and medicinal compounds.
Used in Agrochemical Industry:
7-Bromo-1-chloronaphthalene is utilized as a starting material for the production of agrochemicals, such as pesticides and herbicides, to enhance crop protection and yield.
Safety Precautions:
It is important to handle 7-Bromo-1-chloronaphthalene with caution, as it is classified as a hazardous substance. Exposure to this chemical compound can cause irritation to the skin, eyes, and respiratory system. Proper safety protocols and procedures should be followed when working with 7-Bromo-1-chloronaphthalene to minimize potential health risks.

Upstream product

• 136924-78-2 1-amino-7-bromonaphthalene 
• 843669-39-6 1-Chlor-7-aminonaphthalin 

Relevant academic research and scientific papers

Preparation method of 7-bromine-1-chloronaphthalene

The invention discloses a preparation method of 7-bromine-1-chloronaphthalene, which comprises the following steps of by taking 7-bromine-3, 4-dihydronaphthalene-1 (2H)-ketone as a raw material, mixing the 7-bromine-3, 4-dihydronaphthalene-1 (2H)-ketone, a phosphorus reagent and carbon tetrachloride, and carrying out chlorination reaction to generate 6-bromine-4-chloro-1, 2-dihydronaphthalene, and carrying out aromatization reaction on 6-bromine-4-chloro-1, 2-dihydronaphthalene under the action of an oxidizing agent to generate 7-bromine-1-chloronaphthalene. Compared with a synthesis mode in the prior art, the reaction route has the advantages that the steps are shorter, the adopted reagent is safer and is easy to process, large-scale production is easy to carry out, and the yield is better.

Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.