90956-79-9

Basic information

• Product Name: 3-AMINO-3-(4-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER
• Synonyms: 3-AMINO-3-(4-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER
• CAS NO: 90956-79-9
• Molecular Formula: C11H12ClNO2
• Molecular Weight: 225.674
• Mol File: 90956-79-9.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-AMINO-3-(4-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(4-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER(90956-79-9)
• EPA Substance Registry System: 3-AMINO-3-(4-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER(90956-79-9)

Safety Data

• Hazardous Substances Data: 90956-79-9(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 105-36-2 ethyl bromoacetate 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 99-91-2 para-chloroacetophenone 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 1365265-07-1 ethyl 3-(4-chlorophenyl)-3-oxo-2-(trifluoromethyl)propionate 

Relevant articles and documents

Trifluoroethanol as a Unique Additive for the Chemoselective Electrooxidation of Enamines to Access Unsymmetrically Substituted NH-Pyrroles

An electrochemical method for the synthesis of unsymmetrically substituted NH-pyrroles is described. The synthetic strategy comprises a challenging heterocoupling between two structurally diverse enamines via sequential chemoselective oxidation, addition,

Regioselective Synthesis of N2-Aryl 1,2,3-Triazoles via Electro-oxidative Coupling of Enamines and Aryldiazonium Salts

An efficient synthetic route for the construction of N2-aryl 1,2,3-triazoles is reported via sequential C-N bond formation and electro-oxidative N-N coupling under metal-free conditions. Readily accessible 2-aminoacrylates and aryldiazonium salts were used as starting materials, and the developed protocol displays excellent functional group tolerance, allowing an extensive range of substrate scope up to 91% isolated yield. Various mechanistic studies, along with the isolation of an intermediate adduct, refer to successive ionic and radical reaction sequences.

Divergent Synthesis of Multisubstituted Unsymmetric Pyrroles and Pyrrolin-4-ones from Enamino Esters via Copper-Catalyzed Aerobic Dimerization

A facile synthetic method to access multisubstituted unsymmetric pyrrole and pyrrolin-4-one derivatives is disclosed. In the presence of Cu(OAc)2 and KOAc, substituted pyrrole derivatives are produced in good yields (up to 93 %) through oxidative cyclization of enamino esters. Meanwhile, using CuCl2 and TFA (trifluoroacetic acid), pyrrolin-4-one derivatives are obtained in excellent yields (up to 94 %) through 1,2-aryl migration. A wide range of functional groups have been tolerated, and a reliable method for the synthesis of valuable multisubstituted pyrroles and pyrrolin-4-ones has been developed.