909569-46-6Relevant articles and documents
A concise and straightforward total synthesis of (±)-salinosporamide A, based on a biosynthesis model
Mulholland, Nicholas P,Pattenden, Gerald,Walters, Iain A. S.
experimental part, p. 2782 - 2789 (2009/02/03)
A 14-step total synthesis of (±)-salinosporamide A (1), a potent inhibitor of the 20S proteasome isolated from the marine bacterium Salinospora tropica, is described. The synthesis is based on a diastereoselective intramolecular aldolisation of a substitu