90958-97-7

Basic information

• Product Name: 1H-Pyrimido[1,2-a]quinoxaline, 5-(4-chlorophenyl)-2,3-dihydro-, 6-oxide
• CAS NO: 90958-97-7
• Molecular Formula: C17H14ClN3O
• Molecular Weight: 311.771
• Mol File: 90958-97-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrimido[1,2-a]quinoxaline, 5-(4-chlorophenyl)-2,3-dihydro-, 6-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrimido[1,2-a]quinoxaline, 5-(4-chlorophenyl)-2,3-dihydro-, 6-oxide(90958-97-7)
• EPA Substance Registry System: 1H-Pyrimido[1,2-a]quinoxaline, 5-(4-chlorophenyl)-2,3-dihydro-, 6-oxide(90958-97-7)

Safety Data

• Hazardous Substances Data: 90958-97-7(Hazardous Substances Data)

Upstream product

• 514225-42-4 N-(p-chlorophenylacetyl)-N'-(o-nitrophenyl)-1,3-propanediamine 
• 25026-34-0 4-chlorophenacetyl chloride 
• 145315-42-0 N₁-(2-nitrophenyl)propane-1,3-diamine 
• 112030-59-8 2-(4-Chloro-benzyl)-1,4,5,6-tetrahydro-pyrimidine 
• 1493-27-2 ortho-nitrofluorobenzene 

Relevant articles and documents

Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi

Two different families of N-oxide containing heterocycles were evaluated as in vitro growth inhibitors of T. cruzi. Both families of heterocycles were selected from our in-house library of compounds as analogues of active anti-T. cruzi N-oxide containing heterocycles. Derivatives from pyrimido[1,2-a]quinoxaline 6-oxide family were poorly active at the assayed doses. However, phenazine 5,10-dioxide derivatives displayed good to excellent anti-T. cruzi activities. The anti-T. cruzi activity of phenazine derivatives was related to substituent' electronic descriptors, σp-. Derivatives 19, 20 and 23 were the most cytotoxic compounds against the protozoan and became excellent hit for further structural modifications.

Heterocyclic N-Oxides: Part I - Syntheses of 1,2-Dihydroimidazoquinoxaline 5-Oxides & 2,3-Dihydro-1H-pyrimidoquinoxaline 6-Oxides & Their Antiprotozoal Activity

various new substituted 1,2-dihydroimidazoquinoxaline 5-oxides (3,6-16) and 2,3-dihydro-1H-pyrimidoquinoxaline 6-oxides (17-29) have been synthesized.Compounds 11 and 19 display good antiamoebic activity in vivo against Entamoeba histolytica in intestinal and hepatic amoebiasis.