909781-97-1Relevant articles and documents
Synthesis and evaluation of α-helix mimetics based on a trans-fused polycyclic ether: sequence-selective binding to aspartate pairs in α-helical peptides
Oguri, Hiroki,Tanabe, Shintaro,Oomura, Akifumi,Umetsu, Mitsuo,Hirama, Masahiro
, p. 5801 - 5805 (2006)
Inspired by the topological similarity between ladder-like cyclic ether skeletons and α-helical peptides, a trans-fused 6/6/6/6 tetracyclic ether containing two hydroxyl groups separated by a distance of 4.8 A? was designed as a scaffold for a nonpeptidic