909782-32-7

Basic information

• Product Name: 4-amino-N-(2-methylquinolin-8-yl)benzenesulfonamide
• Synonyms: 4-amino-N-(2-methylquinolin-8-yl)benzenesulfonamide
• CAS NO: 909782-32-7
• Molecular Weight: 313.38
• Mol File: 909782-32-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-amino-N-(2-methylquinolin-8-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-N-(2-methylquinolin-8-yl)benzenesulfonamide(909782-32-7)
• EPA Substance Registry System: 4-amino-N-(2-methylquinolin-8-yl)benzenesulfonamide(909782-32-7)

Safety Data

• Hazardous Substances Data: 909782-32-7(Hazardous Substances Data)

Upstream product

• 18978-78-4 2-methyl-8-aminoquinoline 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 901294-65-3 N-(2-methylquinol-8-yl)-p-acetylaminobenzenesulfonamide 

Downstream Products

• 909782-33-8 C₁₉H₁₄Cl₂N₆O₂S 
• 1173881-89-4 C₂₀H₁₉N₃O₅S 

Relevant articles and documents

Synthesis, molecular structure, anticancer activity, and QSAR study of N-(Aryl/heteroaryl)-4-(1h-pyrrol-1-yl)benzenesulfonamide derivatives

A series of N-(aryl/heteroaryl)-4-(1H-pyrrol-1-yl)benzenesulfonamides were synthesized from 4-amino-N-(aryl/heteroaryl)benzenesulfonamides and 2,5-dimethoxytetrahydrofuran. All the synthesized compounds were evaluated for their anticancer activity on HeLa, HCT-116, and MCF-7 human tumor cell lines. Compound 28, bearing 8-quinolinyl moiety, exhibited the most potent anticancer activity against the HCT-116, MCF-7, and HeLa cell lines, with IC50 values of 3, 5, and 7 μM, respectively. The apoptotic potential of the most active compound (28) was analyzed through various assays: phosphatidylserine translocation, cell cycle distribution, and caspase activation. Compound 28 promoted cell cycle arrest in G2/M phase in cancer cells, induced caspase activity, and increased the population of apoptotic cells. Relationships between structure and biological activity were determined by the QSAR (quantitative structure activity relationships) method. Analysis of quantitative structure activity relationships allowed us to generate OPLS (Orthogonal Projections to Latent Structure) models with verified predictive ability that point out key molecular descriptors influencing benzenosulfonamide’s activity.

Convenient and highly effective fluorescence sensing for Hg2+ in aqueous solution and thin film

A quinolinocyclodextrin, that is, MQAS-β-cyclodextrin (MQAS = N-(2-methyl-8-amino- quinolyl)-p-aminobenzene sulfonamide) was synthesized. Further experiments showed that it could form very stable stoichiometric 2:1 complex with Zn2+ in water. Significantly, the resultant quinolinocyclodextrin/Zn2+ complex showed the specific fluorescence response to Hg2+ over other metal ions, which could be readily distinguished in either aqueous solution or the PVA-based thin film. This finding would enable Zn·32 complex as a convenient and highly efficient fluorescence sensor for the detection of Hg2+.