909863-41-8Relevant articles and documents
Inhibitors of epidermal growth factor receptor tyrosine kinase: Optimisation of potency and in vivo pharmacokinetics
Ballard, Peter,Bradbury, Robert H.,Harris, Craig S.,Hennequin, Laurent F.A.,Hickinson, Mark,Kettle, Jason G.,Kendrew, Jane,Klinowska, Teresa,Ogilvie, Donald J.,Pearson, Stuart E.,Williams, Emma J.,Wilson, Ingrid
, p. 4908 - 4912 (2008/09/21)
The structure-activity and structure-property relationships of anilinoquinazoline inhibitors of EGFR were investigated. Strategies to lower volume of distribution and shorten half-life through structure and pKa modulation are discussed.