909867-59-0

Basic information

• Product Name: 3-(1-hydroxy-butyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester
• Synonyms: 3-(1-hydroxy-butyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester
• CAS NO: 909867-59-0
• Molecular Weight: 317.385
• Mol File: 909867-59-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(1-hydroxy-butyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-hydroxy-butyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester(909867-59-0)
• EPA Substance Registry System: 3-(1-hydroxy-butyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester(909867-59-0)

Safety Data

• Hazardous Substances Data: 909867-59-0(Hazardous Substances Data)

Upstream product

• 123-72-8 butyraldehyde 
• 190906-91-3 3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester 
• 620-08-6 4-methoxypyridine 

Downstream Products

• 919366-55-5 1-benzyloxycarbonyl-3-butylidene-2,3-dihydro-2-methyl-4-pyridone 
• 909867-63-6 1-benzyloxycarbonyl-3-[1-(methylsulfonyloxy)butyl]-2,3-dihydro-2-methyl-4-pyridone 

Relevant articles and documents

4-Pyridone derivatives as new inhibitors of bacterial enoyl-ACP reductase FabI

Bacterial FAS provides essential fatty acids for use in the assembly of key cellular components. Among them, FabI is an enoyl-ACP reductase which catalyzes the final and rate-limiting step of bacterial FAS. It is a potential target for selective antibacterial action, because it shows low overall sequence homology with mammalian enzymes. Until today, various compounds have been reported as inhibitors of bacterial FabI-inhibitory compounds. To discover novel small-molecular FabI inhibitors, we initially screened our compound library for inhibitory activity toward FabI of Escherichia coli. And discovered 4-pyridone derivatives as a lead compound. Structure optimization studies yielded 4-pyridone derivatives 7n having strong FabI-inhibitory and antibacterial activities against Staphylococcus aureus. There have been no reports concerning 4-pyridone derivatives as FabI inhibitor.