90997-79-8Relevant academic research and scientific papers
PALLADIUM-CATALYZED CYCLIZATION REACTIONS. UNICQUE SYNTHESIS OF CONDENSED THIAZOLES
Mizutani, Masato,Sanemitsu, Yuzuru,Tamaru, Yoshinao,Yoshida, Zen-Ichi
, p. 305 - 314 (2007/10/02)
The facile synthesis of 3-methylene-2,3-dihydro-5H-thiazolopyrimidin-5-ones (9) has been performed by the catalytic action of a Pd(II) salt on 4-propargylthiopyrimidin-2(1H)-ones (6).Similar Pd(II)-catalyzed cyclization of 3-propargylthio-1,2,4-triazin-5(2H)-ones (10) gives 6-methylene-6,7-dihydro-4H-thiazolotriazin-4-ones (11) as a main product. 3-methylene-2,3-dihydro-7H-thiazolotriazin-7-ones (12), the regioisomers of 11, are provided by a base-catalyzed cyclization of 10.
PALLADIUM-CATALYZED CYCLIZATION REACTIONS OF 3-PROPARGYLTHIO-1,2,4-TRIAZIN-5(2H)-ONES TO THIAZOLO-1,2,4-TRIAZINONES
Mizutani, Masato,Sanemitsu, Yuzuru,Tamaru, Yoshinao,Yoshida, Zen-ichi
, p. 1237 - 1240 (2007/10/02)
Selective transformation of 3-propargylthio-1,2,4-triazin-5(2H)-ones (1) to 6-methylene-6,7-dihydro-4H-thiazolo- triazin-4-ones (2) and 3-methylene-2,3-dihydro-7H-thiazolotriazin-7-ones (3) is performed under the conditions of Pd(II) salt or sodium hydroxide catalysis, respectively.
