910026-73-2

Upstream product

• 31252-42-3 4-benzylpyperidine 
• 73903-18-1 5-nitro-1⁽³⁾H-benzoimidazole-2-carboxylic acid 
• 74527-55-2 N-butyl-1H-benzo[d]imidazole-2-carboxamide 
• 88-74-4 2-nitro-aniline 
• 17293-40-2 ethyl 2-((2-nitrophenyl)amino)-2-oxoacetate 
• 2849-93-6 2-benzimidazolecarboxylic acid 
• 74527-53-0 N-butyl-N'-(2-nitro-phenyl)-oxalamide 
• 910026-59-4 N-(2-amino-phenyl)-N'-butyl-oxalamide 

Downstream Products

• 910026-71-0 [6-amino-1H-benzimidazol-2-yl]-(4-benzyl-piperidin-1-yl)-methanone 
• 910026-71-0 C₂₀H₂₂N₄O 

Relevant academic research and scientific papers

Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides

(4-Benzylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-yl)-methanone (6a) derived from (E)-1 -(4-benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was identified as a potent NR2B subunit-selective antagonist of the NMDA receptor. To establish the structu

Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

A novel series of benzimidazole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of some structural elements, like H-bond donor groups placed on the benzimidazole skeleton and the substitution pattern of the piperidine ring, on the biological activity was studied. Compound 6a showed excellent analgetic activity in the mouse formalin test following po administration.