910028-19-2Relevant academic research and scientific papers
Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase
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Paragraph 0724, (2017/01/23)
This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
PROCESS FOR THE SYNTHESIS OF (+) AND (-) -1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE
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Page/Page column 12, (2008/06/13)
The present invention is concerned with novel processes for the preparation of (+)-l-(3,4- dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and (-)- l-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutic
Stereocontrolled synthesis of trisubstituted cyclopropanes: Expedient, atom-economical, asymmetric syntheses of (+)-bicifadine and DOV21947
Xu, Feng,Murry, Jerry A.,Simmons, Bryon,Corley, Edward,Fitch, Kenneth,Karady, Sandor,Tschaen, David
, p. 3885 - 3888 (2007/10/03)
An expedient, atom-economical, asymmetric synthesis of 1-aryl-3- azabicyclo[3.1.0]hexanes, including (+)-Bicifadine and DOV21947, in a single-stage through process without isolation of any intermediates has been developed. The key of this synthesis is the in-depth mechanistic understanding of the complicated epoxy nitrile coupling at each reaction stage. Therefore, the desired trisubstituted cyclopropane can be prepared in high ee and yield by controlling the reaction pathway through manipulating the nitrile anion aggregation state.
