910028-19-2

Basic information

• Product Name: [(1S,2R)-2-(aminomethyl)-2-(3,4-dichlorophenyl)cyclopropyl]methanol
• Synonyms: [(1S,2R)-2-(aminomethyl)-2-(3,4-dichlorophenyl)cyclopropyl]methanol
• CAS NO: 910028-19-2
• Molecular Weight: 246.136
• Mol File: 910028-19-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [(1S,2R)-2-(aminomethyl)-2-(3,4-dichlorophenyl)cyclopropyl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [(1S,2R)-2-(aminomethyl)-2-(3,4-dichlorophenyl)cyclopropyl]methanol(910028-19-2)
• EPA Substance Registry System: [(1S,2R)-2-(aminomethyl)-2-(3,4-dichlorophenyl)cyclopropyl]methanol(910028-19-2)

Safety Data

• Hazardous Substances Data: 910028-19-2(Hazardous Substances Data)

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 

Downstream Products

• 1004522-45-5 [(1R,2S)-2-(chloromethyl)-1-(3,4-dichlorophenyl)cyclopropyl]methanamine hydrochloride 

Relevant articles and documents

Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase

This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

Stereocontrolled synthesis of trisubstituted cyclopropanes: Expedient, atom-economical, asymmetric syntheses of (+)-bicifadine and DOV21947

An expedient, atom-economical, asymmetric synthesis of 1-aryl-3- azabicyclo[3.1.0]hexanes, including (+)-Bicifadine and DOV21947, in a single-stage through process without isolation of any intermediates has been developed. The key of this synthesis is the in-depth mechanistic understanding of the complicated epoxy nitrile coupling at each reaction stage. Therefore, the desired trisubstituted cyclopropane can be prepared in high ee and yield by controlling the reaction pathway through manipulating the nitrile anion aggregation state.