910028-22-7

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 910028-70-5 (1R,2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-(3,4-dichlorophenyl)cyclopropanecarbonitrile 
• 910028-67-0 (1S)-1-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-cyano-2-(3,4-dichlorophenyl)ethyl 4-methylbenzenesulfonate 
• 910028-65-8 (3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile 

Downstream Products

• 910028-58-9 (1R,5S)-1-(3,4-dichlorophenyl)-3-oxabicyclo[3.1.0]hexan-2-one 

Relevant academic research and scientific papers

NOVEL ARYLBICYCLO[3.1.0]HEXYLAMINES AND METHODS AND COMPOSITIONS FOR THEIR PREPARATION AND USE

The invention provides novel arylbicyclo[3.1.OJhexylamines, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system

PROCESS FOR THE SYNTHESIS OF (+) AND (-) -1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE

The present invention is concerned with novel processes for the preparation of (+)-l-(3,4- dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and (-)- l-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutic

Stereocontrolled synthesis of trisubstituted cyclopropanes: Expedient, atom-economical, asymmetric syntheses of (+)-bicifadine and DOV21947

An expedient, atom-economical, asymmetric synthesis of 1-aryl-3- azabicyclo[3.1.0]hexanes, including (+)-Bicifadine and DOV21947, in a single-stage through process without isolation of any intermediates has been developed. The key of this synthesis is the in-depth mechanistic understanding of the complicated epoxy nitrile coupling at each reaction stage. Therefore, the desired trisubstituted cyclopropane can be prepared in high ee and yield by controlling the reaction pathway through manipulating the nitrile anion aggregation state.