910111-61-4Relevant academic research and scientific papers
Diphenylsilane as a coupling reagent for amide bond formation
Sayes, Morgane,Charette, André B.
, p. 5060 - 5064 (2017)
A simple procedure for amide bond formation using diphenylsilane as a coupling reagent is described. This methodology enables the direct coupling of carboxylic acids with primary and secondary amines, releasing only hydrogen and a siloxane as by-products. Only one equivalent of each partner is needed, providing a more sustainable amidation method producing minimal wastes. This methodology was also extended to the synthesis of peptides and lactams by addition of Hünig's base (DIPEA) and 4-dimethylaminopyridine (DMAP).
DPP-IV inhibitors
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Page/Page column 32, (2008/06/13)
The invention relates to compounds of formula (I) wherein Z, R1-7, X and n have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compou
