91012-42-9Relevant academic research and scientific papers
Rongalite and base-promoted cleavage of disulfides and subsequent Michael addition to α,β-unsaturated ketones/esters: an odorless synthesis of β-sulfido carbonyl compounds
Guo, Wenxue,Lv, Guangshu,Chen, Jiuxi,Gao, Wenxia,Ding, Jinchang,Wu, Huayue
supporting information; experimental part, p. 2297 - 2300 (2010/06/16)
A highly practical method to access β-sulfido carbonyl compounds was developed, which could be conducted without any expensive reagent, special apparatus/technique, and no requirement of metal catalysts. β-Sulfido carbonyl compounds were formed at room temperature, in short time and with high chemoselectivity in good to excellent yields. A plausible mechanism for the role of Rongalite, as a promoter for the cleavage of disulfides generating thiolate anions that then undergo facile thia-Michael addition to α,β-unsaturated ketones and esters is proposed.
Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors
Yang, Qingang,Chen, Lili,He, Xuchang,Gao, Zhenting,Shen, Xu,Bai, Donglu
scheme or table, p. 1400 - 1405 (2009/09/29)
The severe acute respiratory syndrome (SARS) coronavirus 3CL protease is an attractive target for the development of anti-SARS drugs. In this paper, cinanserin (1) analogs were synthesized and tested for the inhibitory activities against SARS-coronavirus (CoV) 3CL protease by fluorescence resonance energy transfer (FRET) assay. Four analogs show significant activities, especially compound 26 with an IC50 of 1.06 μM.
