910136-44-6Relevant academic research and scientific papers
Synthesis of 1,1,1-trihalo-4-methoxy-4-[2-heteroaryl]-3-buten-2-ones, the corresponding butan-1,3-dione and azole derivatives
Flores, Alex F.C,Brondani, Sergio,Zanatta, Nilo,Rosa, Adriano,Martins, Marcos A.P
, p. 8701 - 8705 (2002)
The synthesis of 1,1,1-trihalo-4-methoxy-4-[2-thienyl]-3-buten-2-ones, 1,1,1-trihalo-4-methoxy-4-[2-furyl]-3-buten-2-ones and the respective trihalomethyl 1,3-butanone derivatives by trihaloacylation of dimethoxy acetals derived from 2-acetylthiophene and 2-acetylfuran are reported. This is a convenient method to obtain fluorinated and chlorinated 1,3-dielectrophiles from 2-acetylthiophene and 2-acetylfuran. The fluorinated 1,3-dielectrophiles were used to synthesize five new 2-thienyl- and 2-furylazoles. The structure of all products were assigned by 1HH- and 13C NMR and mass spectrometry.
