91017-58-2 Usage
Originator
Abunidazole,ZYF Pharm Chemical
Manufacturing Process
150.0 g (1 mol) of p-tert-butylphenol are dissolved in 1200 ml of anhydrous
ethyl ether and the thus obtained solution is added to a 10% solution of
ethylmagnesium bromide in 1000 ml of anhydrous ether, at room
temperature, under stirring.
After having evaporated the ether, 1000 ml of anhydrous benzene are added and the mixture is distilled, at normal pressure, until its volume is about 2/3
of the original volume. After cooling at room temperature, 1 mol of 1-methyl-
5-nitroimidazolyl-2-carboxyaldehyde in 1000 ml of anhydrous benzene is
added.
The whole is boiled for 1 h, is cooled to about 10°C and is added with 8% HCl
to adjust the pH to 7. Benzene layer is dried and concentrated up to 2/3 of
the volume. The 2-(1-methyl-5-nitro)imidazolyl-1-(2-hydroxy-5-tertbutylphenylcarbinol
is allowed to crystallize, melting point 158°-160°C; yield
0-60%.
Therapeutic Function
Antiprotozoal
Check Digit Verification of cas no
The CAS Registry Mumber 91017-58-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,0,1 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 91017-58:
(7*9)+(6*1)+(5*0)+(4*1)+(3*7)+(2*5)+(1*8)=112
112 % 10 = 2
So 91017-58-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H19N3O4/c1-15(2,3)9-5-6-11(19)10(7-9)13(20)14-16-8-12(17(14)4)18(21)22/h5-8,13,19-20H,1-4H3
91017-58-2Relevant academic research and scientific papers
Preparation, antimicrobial evaluation, and mutagenicity of [2- hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols, [5-tert-butyl-2- methylaminophenyl]-[1-methyl-5-nitro-1H-2-imidazolyl] methanol, and [2- hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl] ketones
Arredondo,Moreno-Manas,Pleixats,Palacin,Raga,Castello,Ortiz
, p. 1959 - 1968 (2007/10/03)
Efficient preparations of the titled compounds are described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are nonmutagenic and present a MIC as low as some of the usual standards in the field.
Preparation, antimicrobial evaluation and mutagenicity of differently substituted [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols
Arredondo,Moreno-Manas,Pleixats,Palacin,Raga,Castello,Ortiz
, p. 1781 - 1784 (2007/10/03)
An efficient preparation of the titled compounds is described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are non mutagenic and present a MIC as low as some of the usual standards in the field.
