91021-31-7Relevant academic research and scientific papers
STUDIES ON PYRIMIDINE DERIVATIVES. XXXI. SYNTHESIS OF CHLOROMETHYLPYRIMIDINES BY REACTION OF MONOMETHYL-PYRIMIDINE N-OXIDES WITH PHOSPHORYL CHLORIDE
Sakamoto, Takao,Kaneda, Sohichi,Hama, Yoshiaki,Yoshizawa, Hiroshi,Yamanaka, Hiroshi
, p. 991 - 994 (2007/10/02)
The reaction of 2- and 6-methylpyrimidine 1-oxides with phosphoryl chloride underwent the selective side-chain chlorination to give 2- and 6-chloromethylpyrimidines as sole products.No by-products such as 2-chloro- and 4-chloropyrimidines were obtained ev
