910235-71-1Relevant articles and documents
Pyrrolopyrimidine BTK inhibitor as well as preparation method and application thereof
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Paragraph 0095; 0104-0105; 0125; 0130-0131, (2021/11/03)
The invention provides a pyrrolopyrimidine BTK inhibitor as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound has the structural general formula shown in a formula (I). In-flight
Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834
Young, Wendy B.,Barbosa, James,Blomgren, Peter,Bremer, Meire C.,Crawford, James J.,Dambach, Donna,Gallion, Steve,Hymowitz, Sarah G.,Kropf, Jeffrey E.,Lee, Seung H.,Liu, Lichuan,Lubach, Joseph W.,Macaluso, Jen,Maciejewski, Pat,Maurer, Brigitte,Mitchell, Scott A.,Ortwine, Daniel F.,Di Paolo, Julie,Reif, Karin,Scheerens, Heleen,Schmitt, Aaron,Sowell, C. Gregory,Wang, Xiaojing,Wong, Harvey,Xiong, Jin-Ming,Xu, Jianjun,Zhao, Zhongdong,Currie, Kevin S.
, p. 1333 - 1337 (2015/03/14)
SAR studies focused on improving the pharmacokinetic (PK) properties of the previously reported potent and selective Btk inhibitor CGI-1746 (1) resulted in the clinical candidate GDC-0834 (2), which retained the potency and selectivity of CGI-1746, but wi
KINASE INHIBITORS, AND METHODS OF USING AND IDENTIFYING KINASE INHIBITORS
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, (2008/06/13)
Methods of inhibiting BTK activity by inhibiting phosphorylation of Y551 of BTK, methods of treating patients by inhibiting BTK activity by inhibiting phosphorylation of Y551 of BTK, chemical entities that bind to BTK and inhibited complexes are provided.