91024-47-4

Usage

Chemical class

Belongs to the phenothiazine class of organic compounds.

Molecular structure

Nitrogen-containing tricyclic molecule with a fused 6-5-6 membered ring system.

Derivative

A derivative of phenothiazine, a heterocyclic compound.

Known use

Phenothiazine is most commonly known for its use as an antipsychotic medication.

Substitution

Contains two methyl groups at the 1 and 4 positions of the phenothiazine ring.

Impact of substitution

The presence of methyl groups can affect the chemical and pharmacological properties of the compound.

Potential applications

Studied for its potential use in pharmaceuticals and organic synthesis.

Current status

Specific applications and uses are still under investigation.

Upstream product

• 527-61-7 2,6-dimethyl-1,4-benzoquinone 
• 137-07-5 2-amino-benzenethiol 
• 137-18-8 2,5-Dimethyl-1,4-benzoquinone 

Relevant academic research and scientific papers

The Carbon 13 NMR Spectra and Electronic Structure of 3H-Phenothiazin-3-one and Its Methyl Derivatives

The 13C NMR chemical shifts of 3H-phenothiazin-3-one (1) and eleven of its methyl derivatives are reported.The effect of including sulfur 3d orbitals is discussed in relation to the 13C chemical shifts.The chemical shifts of 1 can be explained in terms of both the succesive polarization of the long ?-conjugated framework promoted by the carbonyl group and the contribution of the sulfur d-orbitals.The 13C chemical shifts gave a better correlation with the CNDO/2 ?- and total electron densities calculated by means of the sp-basis set than by means of the spd-basis set, but an improved correlation was obtained by reducing the extent of d-orbital participation on sulfur.From the correlation of the 13C chemical shifts with the CNDO/2 sp ?- and the total electron densities of all carbons of 1 and monomethyl derivatives, the proportionality constants of -300 and -180 ppm/e respectively were obtained.

PHENAZINE-3-ONE AND PHENOTHIAZINE-3-ONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS

Disclosed herein are phenazine-3-one and phenothiazine-3-one derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging.