910297-66-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-N-[2-chloro-6-(hydroxyMethyl)phenyl]-acetaMide is used as an intermediate in the preparation of Dasatinib metabolite for the treatment of cancers and immune diseases. It plays a crucial role in the synthesis process, enabling the development of effective therapeutic agents that target specific molecular pathways involved in these conditions.

Upstream product

• 910297-65-3 3-chloro-2-(2-chloroacetamido)benzyl 2-chloroacetate 

Downstream Products

• 910297-68-6 N-(2-chloro-6-(hydroxymethyl)phenyl)-2-(tritylamino)thiazole-5-carboxamide 

Relevant academic research and scientific papers

PROCESS FOR PREPARING N-(2-CHLORO-6-METHYLPHENYL)-2-[[6-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]-2-METHYL-4-PYRIMIDINYL]AMINO] -5-THIAZOLECARBOXAMIDE AND RELATED METABOLITES THEREOF

The present invention is directed to process for the preparation of metabolites as well as the parent compound of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl] amino]-5-thiazolecarboxamide, the compound of formula (I).

'N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites

The present invention is directed to metabolites of ′N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, the compound of formula (I), pharmaceutical compositions thereof, and to methods