91032-37-0 Usage
Description
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxodecyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosylis a complex organic compound with a unique structure and various functional groups. It is an analogue of the family of lipoglycopeptides, which are known for their potent broad-spectrum antibiotic activity.
Uses
Used in Pharmaceutical Industry:
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxodecyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosylis used as an antibiotic for its potent broad-spectrum antibiotic activity against various Gram-positive bacteria, including MRSA and E. faecalis. Its unique structure and functional groups contribute to its effectiveness in combating antibiotic-resistant bacteria.
Used in Research and Development:
Ristomycin A aglycone, 34-O-2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-2-deoxy-2-(8-methyl-1-oxodecyl)amino-.beta.-D-glucopyranosyl-42-O-.alpha.-D-mannopyranosylis also used in research and development for the discovery of new antibiotics and the study of its mechanism of action. Its complex structure and unique functional groups make it an interesting subject for further investigation and potential development of new drugs.
Biological Activity
teicoplanin a2-4 is a major component of the teicoplanin complex [1-3].teicoplanins, lipoglycopeptide antibiotics, are glycopeptide antibiotics mainly produced by a. teichomyceticus that are broadly effective against gram-positive bacteria in vitro. teicoplanins consist of five major components (a2-1, a2-2, a2-3, a2-4 and a2-5), one hydrolysis component (a3-1), and four minor components (rs-1, rs-2, rs-3, rs-4) [1]. teicoplanins have been recently used for the treatment of multitudinous aerobic and anaerobic gram-positive infections. teicoplanins have been rapidly and extensively absorbed from the peritoneal cavity and muscle, but very poorly absorbed from the gastrointestinal tract [2]. teicoplanin is highly bound in plasma to albumin and in tissues. both renal and nonrenal mechanisms have been implicated in the elimination of the drug. for at least after one day administration, the concentrations of teicoplanin in serum and urine exceeded the mic ranging from 0.02-2 μg/ml on many pathogenic organisms [3].
references
[1] bernareggi a, borghi a, borgonovi m, et al. teicoplanin metabolism in humans[j]. antimicrobial agents and chemotherapy, 1992, 36(8): 1744-1749.[2] rowland m. clinical pharmacokinetics of teicoplanin[j]. clinical pharmacokinetics, 1990, 18(3): 184-209.[3] traina g l, bonati m. pharmacokinetics of teicoplanin in man after intravenous administration[j]. journal of pharmacokinetics and pharmacodynamics, 1984, 12(2): 119-128.
Check Digit Verification of cas no
The CAS Registry Mumber 91032-37-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,0,3 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 91032-37:
(7*9)+(6*1)+(5*0)+(4*3)+(3*2)+(2*3)+(1*7)=100
100 % 10 = 0
So 91032-37-0 is a valid CAS Registry Number.
InChI:InChI=1/C89H99Cl2N9O33/c1-4-34(2)9-7-5-6-8-10-61(109)95-69-75(114)72(111)59(32-102)130-88(69)133-79-56-26-41-27-57(79)127-53-18-14-39(24-48(53)91)78(132-87-68(93-35(3)104)74(113)71(110)58(31-101)129-87)70-85(122)99-67(86(123)124)46-29-43(106)30-55(128-89-77(116)76(115)73(112)60(33-103)131-89)62(46)45-23-38(13-15-50(45)107)64(82(119)100-70)97-84(121)66(41)98-83(120)65-40-21-42(105)28-44(22-40)125-54-25-37(12-16-51(54)108)63(92)81(118)94-49(80(117)96-65)20-36-11-17-52(126-56)47(90)19-36/h11-19,21-30,34,49,58-60,63-78,87-89,101-103,105-108,110-116H,4-10,20,31-33,92H2,1-3H3,(H,93,104)(H,94,118)(H,95,109)(H,96,117)(H,97,121)(H,98,120)(H,99,122)(H,100,119)(H,123,124)/t34?,49-,58-,59-,60-,63+,64-,65+,66-,67-,68-,69-,70+,71-,72-,73-,74-,75-,76+,77+,78-,87+,88+,89+/m1/s1
