910322-51-9

Basic information

• Product Name: benzyl2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate
• Synonyms: benzyl2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate
• CAS NO: 910322-51-9
• Molecular Weight: 282.299
• Mol File: 910322-51-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate(910322-51-9)
• EPA Substance Registry System: benzyl2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate(910322-51-9)

Safety Data

• Hazardous Substances Data: 910322-51-9(Hazardous Substances Data)

Upstream product

• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 5437-45-6 Benzyl bromoacetate 
• 615-16-7 1H-benzimidazol-2-ol 

Downstream Products

• 910322-52-0 (3-methyl-2-oxo-2,3-dihydrobenzoimidazol-1-yl)acetic acid benzyl ester 
• 910322-55-3 (3-ethyl-2-oxo-2,3-dihydrobenzoimidazol-1-yl)acetic acid benzyl ester 
• 104189-85-7 2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetic acid 

Relevant articles and documents

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells

Olaparib is a PARP inhibitor (PARPi). For patients bearing BRCA1 or BRCA2 mutations, olaparib is approved to treat ovarian cancer and in clinical trials to treat breast and pancreatic cancers. In BRCA2-defective patients, PARPi inhibits DNA single-strand break repair, while BRCA2 mutations hamper double-strand break repair. Recently, we identified a series of triazole derivatives that mimic BRCA2 mutations by disrupting the Rad51-BRCA2 interaction and thus double-strand break repair. Here, we have computationally designed, synthesized, and tested over 40 novel derivatives. Additionally, we designed and conducted novel biological assays to characterize how they disrupt the Rad51-BRCA2 interaction and inhibit double-strand break repair. These compounds synergized with olaparib to target pancreatic cancer cells with functional BRCA2. This supports the idea that small organic molecules can mimic genetic mutations to improve the profile of anticancer drugs for precision medicine. Moreover, this paradigm could be exploited in other genetic pathways to discover innovative anticancer targets and drug candidates.

Ramoplanin derivatives possessing antibacterial activity

Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.