910333-33-4Relevant academic research and scientific papers
Synthesis and activity of tyropeptin A derivatives as potent and selective inhibitors of mammalian 20S proteasome
Momose, Isao,Umezawa, Yoji,Hirosawa, Sehei,Iijima, Masatomi,Iinuma, Hironobu,Ikeda, Daishiro
, p. 1733 - 1742 (2008/02/03)
Tyropeptin A, a potent proteasome inhibitor, was isolated from the culture broth of Kitasatospora sp. MK993-dF2. We synthesized the derivatives of tyropeptin A to enhance its inhibitory potency. Among the synthesized derivatives, the most potent compound,
