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5-(4-TRIFLUOROMETHOXY-PHENYL)-[1,3,4]OXADIAZOL-2-YLAMINE is a complex organic compound with the molecular formula C10H7F3N3O2. It features a 1,3,4-oxadiazole core, which is a five-membered heterocyclic ring containing two nitrogen atoms and one oxygen atom. The compound is characterized by the presence of a 4-trifluoromethoxy-phenyl group attached to the 5-position of the oxadiazole ring. This specific arrangement of atoms and functional groups endows the molecule with unique chemical and physical properties, making it potentially useful in various applications, such as pharmaceuticals or materials science, where its stability and reactivity could be exploited.

910442-23-8

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910442-23-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 910442-23-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,0,4,4 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 910442-23:
(8*9)+(7*1)+(6*0)+(5*4)+(4*4)+(3*2)+(2*2)+(1*3)=128
128 % 10 = 8
So 910442-23-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H6F3N3O2/c10-9(11,12)17-6-3-1-5(2-4-6)7-14-15-8(13)16-7/h1-4H,(H2,13,15)

910442-23-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[4-(trifluoromethoxy)phenyl]-1,3,4-oxadiazol-2-amine

1.2 Other means of identification

Product number -
Other names F2145-0213

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:910442-23-8 SDS

910442-23-8Downstream Products

910442-23-8Relevant academic research and scientific papers

Synthesis, telomerase inhibitory and anticancer activity of new 2-phenyl-4H-chromone derivatives containing 1,3,4-oxadiazole moiety

Han, Xu,Liu, Xin Hua,Ma, Duo,Yu, Yun Long,Zhang, Zhao Yan

, p. 344 - 360 (2021)

Based on previous studies, 66 2-phenyl-4H-chromone derivatives containing amide and 1,3,4-oxadiazole moieties were prepared as potential telomerase inhibitors. The results showed most of the title compounds exhibited significantly inhibitory activity on telomerase. Among them, some compounds demonstrated the most potent telomerase inhibitory activity (IC50 50 = 6.41 μM). In addition, clear structure–activity relationships were summarised, indicating that the substitution of the methoxy group and the position, type and number of the substituents on the phenyl ring had significant effects on telomerase activity. Among them, compound A33 showed considerable inhibition against telomerase. Flow cytometric analysis showed that compound A33 could arrest MGC-803 cell cycle at G2/M phase and induce apoptosis in a concentration-dependent way. Meanwhile, Western blotting revealed that this compound could reduce the expression of dyskerin, which is a fragment of telomerase.

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