910443-00-4Relevant academic research and scientific papers
New method of preparation of C2F5Li and its reactions with cyclic imines and lactims: Synthesis of α-pentafluoroethyl proline
Shevchenko, Nikolay E.,Nenajdenko, Valentine G.,R?schenthaler, Gerd-Volker
, p. 390 - 396 (2008/12/21)
Addition of pentafluoroethyllithium to cyclic imines leads to pentafluoroethyl substituted pyrrolidines, piperidines and azepanes while reaction of cyclic lactims gives rise to 2-pentafluoroethyl imines. Oxidative cleavage of 2-furyl-2-pentafluoroethyl pyrrolidine has been found to be an effective method for the preparation of a racemic α-pentafluoroethyl proline.
