910443-83-3

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINOMETHYL-3-(4-FLUORO-PHENYL)-PROPIONIC ACID is used as a pain management medication for treating acute and chronic pain conditions such as muscular pain, neuropathic pain, and postoperative pain. Its application is based on its ability to modulate potassium channels in the central nervous system, thereby inhibiting pain signals and providing effective pain relief without the adverse effects linked to opioid use.
Used in Pain Management:
2-AMINOMETHYL-3-(4-FLUORO-PHENYL)-PROPIONIC ACID serves as an analgesic agent, offering an alternative to opioid medications. It is particularly beneficial for patients requiring long-term pain management, as it does not lead to tolerance, dependence, or withdrawal symptoms, thus improving patient safety and quality of life.

InChI:InChI=1/C10H12FNO2/c11-9-3-1-7(2-4-9)5-8(6-12)10(13)14/h1-4,8H,5-6,12H2,(H,13,14)

Upstream product

• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 72707-66-5 2-(bromomethyl)acrylic acid 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 

Relevant academic research and scientific papers

Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids

We report here a scalable, catalytic one-pot approach to enantiopure and unmodified β2-amino acids. A newly developed confined imidodiphosphorimidate (IDPi) catalyzes a broadly applicable reaction of diverse bis-silyl ketene acetals with a silylated aminomethyl ether, followed by hydrolytic workup, to give free β2-amino acids in high yields, purity, and enantioselectivity. Importantly, both aromatic and aliphatic β2-amino acids can be obtained using this method. Mechanistic studies are consistent with the aminomethylation to proceed via silylium-based asymmetric counteranion-directed catalysis (Si-ACDC) and a transition state to explain the enantioselectivity is suggested on the basis of density functional theory calculation.

Enzymatic multicomponent reaction for simultaneous synthesis of two important scaffolds, pyridin-2-ones and α-alkylated nitriles

An efficient approach for the synthesis of highly substituted pyridin-2-one derivatives and α-alkylated nitriles through enzymatic multicomponent reaction (MCR) was developed. This MCR involved bio-mimetic reduction between 3,4-dihydropyridin-2-one and activated olefin, both of which were in situ generated in the Acylase Amano (AA)-catalyzed domino reaction starting from benzaldehyde, cyanoacetamide and ketone. A wide range of substituted benzaldehydes and ketones were accepted by this reaction. Both final products (pyridin-2-one derivatives and α-alkylated nitriles) were important skeletons and synthetic intermediates. The synthetic application of prepared α-alkylated nitrile was demonstrated by converting it into the corresponding α-alkyl-β2-amino acid with high yield.

Radiochemical 18F-fluoroarylation of unsaturated α-, β- and γ-amino acids, application to a radiolabelled analogue of baclofen

Unsaturated α-, β- and γ-amino acids have been investigated as substrates for the reductive Meerwein arylation. Radical reactions of this type have been shown to be a valuable tool for the fast and efficient introduction of the 4-[18F]fluorophenyl group into precursor molecules allowing short-time syntheses of potential PET radiotracers, which would be more difficult to access by other methods.