910470-69-8

Upstream product

• 861323-61-7 4-(carboxymethyl)-3,5-dimethylbenzoic acid 
• 943741-22-8 2-(4-bromo-2,6-dimethylphenyl)ethanol 
• 206559-43-5 5-bromo-2-iodo-1,3-dimethyl-benzene 
• 34137-14-9 methyl 4-hydroxy-3,5-dimethylbenzoate 
• 4919-37-3 3,5-dimethyl-4-hydroxybenzoic acid 
• 576-26-1 2.6-dimethylphenol 
• 910470-68-7 3,5-dimethyl-4-trimethylsilanylethynyl-benzoic acid methyl ester 
• 341006-48-2 methyl 3,5-dimethyl-4-{[(trifluoromethyl)sulfonyl]oxy}benzoate 

Downstream Products

• 910470-84-7 acetic acid 2-(4-acetoxymethyl-3-iodo-2,6-dimethyl-phenyl)-ethyl ester 
• 910470-71-2 2,2-dimethyl-propionic acid 2-[4-(2,2-dimethyl-propionyloxymethyl)-3-iodo-2,6-dimethyl-phenyl]-ethyl ester 
• 910470-87-0 2,2-dimethyl-propionic acid 2-acetyl-4-[2-(2,2-dimethyl-propionyloxy)-ethyl]-3,5-dimethyl-benzyl ester 
• 910470-86-9 2,2-dimethyl-propionic acid 4-[2-(2,2-dimethyl-propionyloxy)-ethyl]-2-ethynyl-3,5-dimethyl-benzyl ester 
• 910470-88-1 2,2-dimethyl-propionic acid 4-[2-(2,2-dimethyl-propionyloxy)-ethyl]-2-methanesulfonyloxyacetyl-3,5-dimethyl-benzyl ester 
• 910470-85-8 2,2-dimethyl-propionic acid 4-[2-(2,2-dimethyl-propionyloxy)-ethyl]-3,5-dimethyl-2-trimethylsilanylethynyl-benzyl ester 
• 910470-83-6 acetic acid 2-(4-acetoxymethyl-2,6-dimethyl-phenyl)-ethyl ester 

Relevant academic research and scientific papers

Final-Stage Site-Selective Acylation for the Total Syntheses of Multifidosides A-C

The first total syntheses of multifidosides A-C have been achieved. The synthetic strategy is characterized by catalytic site-selective acylation of unprotected glycoside precursors in the final stage of the synthesis. High functional-group tolerance of the site-selective acylation, promoted by an organocatalyst, enabled the conventionally difficult molecular transformation in a predictable and reliable manner. An advantage of this strategy is to avoid the risks of undesired side reactions during the removal of the protecting groups at the final stage of the total synthesis.

Total synthesis of pterosines B and C via a photochemical key step

A total synthesis of pterosines B and C is reported. Starting with a fourfold substituted benzene derivative, the introduction of the remaining substituents is mainly based on Sonogashira couplings followed by different transformations of the ethyne moiety. The key step is a photochemical ring-closure of an α-mesyloxy ketone forming the 1-indanone skeleton. Georg Thieme Verlag Stuttgart.