910484-84-3Relevant articles and documents
Stereocontrolled synthesis of gem-difluoromethylenated goniodiols and goniothalamin epoxides based on ring-closing metathesis
You, Zheng-Wei,Zhang, Xingang,Qing, Feng-Ling
, p. 2535 - 2542 (2006)
An efficient and general method to stereoselectively synthesize gem-difluoromethylenated goniodiols and goniothalamin epoxides has been developed. The introduction of a gem-difluoromethyl-containing group was achieved by the reaction of aldehydes with 3-bromo-3,3-difluoropropene in the presence of indium. The gem-difluoromethylenated α,β-unsaturated- δ-lactone moiety was constructed through the ring-closing metathesis of highly electron-deficient gew-difluoromethylenated acryloyl esters by Grubbs' II catalyst in toluene at reflux. Georg Thieme Verlag Stuttgart.