910550-98-0Relevant academic research and scientific papers
Dipeptidyl peptidase-4 inhibitor with β-amino amide scaffold: Synthesis, SAR and biological evaluation
Kim, Heung Jae,Kwak, Woo Young,Min, Jong Pil,Sung, Si Young,Kim, Ha Dong,Kim, Mi Kyung,Kim, Hae Sun,Park, Kyung Jin,Son, Moon Ho,Kim, Soon Hoe,Lee, Bong Jin
, p. 5545 - 5549 (2012/09/22)
Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. Several series of β-amino amide containing piperazine derivatives have been prepared and evaluated as a inhibitor of DPP4. Finally compound 5m was selected for further evaluation.
PIPERAZINYL COMPOUNDS
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Page/Page column 35, (2010/11/23)
A compound of formula (I) or a pharmaceutically acceptable salt thereof: [wherein Ar is aryl or heteroaryl, optionally substituted; R1 is acyl; R2 is H or lower alkyl; R3 is H, and the like; R4 is H, and the like.] having the activity inhibiting DPP-IV ac
