910567-85-0Relevant articles and documents
Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists
Tian, Xinrong,Mishra, Rajesh K.,Switzer, Adrian G.,Hu, X. Eric,Kim, Nick,Mazur, Adam W.,Ebetino, Frank H.,Wos, John A.,Crossdoersen, Doreen,Pinney, Beth B.,Farmer, Julie A.,Sheldon, Russell J.
, p. 4668 - 4673 (2006)
The design and synthesis of a series of potent 1,3,4-trisubstituted-2-oxopiperazine based MC4 agonists are described. The tripeptidomimetic analogs (12a,b and 23) and the dipeptidomimetic 27 displayed single-nanomolar binding affinity and agonist potency