910577-02-5Relevant academic research and scientific papers
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site
Gopalsamy, Ariamala,Chopra, Rajiv,Lim, Kitae,Ciszewski, Gregory,Shi, Mengxiao,Curran, Kevin J.,Sukits, Steven F.,Svenson, Kristine,Bard, Joel,Ellingboe, John W.,Agarwal, Atul,Krishnamurthy, Girija,Howe, Anita Y. M.,Orlowski, Mark,Feld, Boris,O'Connell, John,Mansour, Tarek S.
, p. 3052 - 3055 (2006)
Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor. Optimization of various regions of the lead molecule resulted in compounds that displayed good potency and selectivity.
SULFONAMIDE DERIVATIVES TO TREAT INFECTION WITH HEPATITIS C VIRUS
-
Page/Page column 17, (2008/06/13)
This invention is directed to compounds of formula (I): wherein R1, R2, X, and n are as defined herein, including all crystalline forms and pharmaceutically acceptable salts thereof, with the provisos that when X is CH2, n
