910577-23-0Relevant academic research and scientific papers
An ionic liquid as reaction medium for the synthesis of halo-containing β-enaminones at room temperature
Martins, Marcos A. P.,Guarda, Emerson A.,Frizzo, Clarissa P.,Marzari, Mara R. B.,Moreira, Dayse N.,Zanatta, Nilo,Bonacorso, Helio G.
experimental part, p. 1321 - 1327 (2009/12/04)
A series of twenty halomethylated β-enaminones [RC(O)CH=C(R 1)NR 3 R 4, where R = CF3,CCl 3, CHCl2; R 1 = H, Me, Ph; R 3 = H, Me, Bu, Et; R 4 = Me, Et, Bu, allyl, tert-amyl, CH2CH 2OH, Bn, Ph] were synthesized using the ionic liquid [bmim]BF 4 at room temperature. It is demonstrated that this ionic liquid is a reaction medium suitable for the amination of β-alkoxyvinyl halomethyl ketones. The advantages of this method are the absence of solvents, short reaction times, and good yields.
