910581-18-9

Upstream product

• 501-52-0 3-Phenylpropionic acid 
• 107978-04-1 3-(1-oxo-3-phenylpropyl)-1,3-oxazolidin-2-one 
• 910581-11-2 tert-butyl 3-benzyl-4-oxo-4-(2-oxooxazolidin-3-yl)butanoate 

Downstream Products

• 106847-88-5 3-benzyl-1-hydroxypyrrolidine-2,5-dione 
• 910581-40-7 2-benzyl-N¹-(prop-2-ynyl)-N⁴-(trityloxy)succinamide 
• 910581-32-7 2-benzyl-4-oxo-4-(trityloxyamino)butanoic acid 
• 910581-48-5 2-benzyl-N⁴-hydroxy-N¹-(prop-2-ynyl)succinamide 
• 910581-25-8 3-benzyl-4-oxo-4-(2-oxooxazolidin-3-yl)-N-(trityloxy)butanamide 

Relevant academic research and scientific papers

Rapid assembly of matrix metalloprotease inhibitors using click chemistry

A panel of 96 metalloprotease inhibitors was assembled using "click chemistry" by reacting eight zinc-binding hydroxamate warheads with 12 azide building blocks. Screens of the bidentate compounds against representative metalloproteases provided discerning inhibition fingerprints, revealing compounds with low micromolar potency against MMP-7. The relative ease and convenience of the strategy in constructing focused chemical libraries for rapid in situ screening of MMPs is thereby demonstrated.