910582-16-0Relevant academic research and scientific papers
Andrographolide decahydronaphthalene structure modified derivative series I and its preparation and use (by machine translation)
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Paragraph 0087; 0088, (2019/05/22)
The invention belongs to the field of medical technology, discloses andrographolide derivatives in the preparation of the prevention and treatment of human tissue, organ fibrosis of application, in particular to andrographolide decahydronaphthalene struct
Design, synthesis, and biological evaluation of andrographolide derivatives as potent hepatoprotective agents
Tang, Chunlei,Gu, Guolong,Wang, Bin,Deng, Xin,Zhu, Xiaoyun,Qian, Hai,Huang, Wenlong
, p. 324 - 333 (2014/03/21)
Poor water solubility limits the clinical use of andrographolide and its derivatives. In an attempt to develop potent hepatoprotective drugs, a strategy was proposed to improve the aqueous solubility of andrographolide. Ten andrographolide derivatives were designed, synthesized, evaluated for aqueous solubility and in vivo hepatoprotective activity against CCl4-induced liver injury in mice. As expected, the aqueous solubility of synthetic derivatives was effectively improved. All compounds demonstrated the effect of different degrees in improving the liver enzyme (ALT and AST) activity, especially the most promising compound 9d significantly improved liver enzyme activity, with high potency to be a new lead.
Synthesis and anti-HIV-evaluation of novel andrographolide derivatives
Gu, Guolong,Lin, Haiyan,Liu, Yajuan,Yang, Liumeng,Zheng, Yongtang,Wang, Bin,Tang, Chunlei,Qian, Hai,Huang, Wenlong
, p. 155 - 163 (2013/08/22)
A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.
