910606-15-4

Basic information

• Product Name: 4-[4-(3-cyclopropylmethoxy-pyridin-2-yl)-piperazin-1-yl]-cyclohexylamine
• Synonyms: 4-[4-(3-cyclopropylmethoxy-pyridin-2-yl)-piperazin-1-yl]-cyclohexylamine
• CAS NO: 910606-15-4
• Molecular Weight: 330.473
• Mol File: 910606-15-4.mol

Chemical Properties

• CAS DataBase Reference: 4-[4-(3-cyclopropylmethoxy-pyridin-2-yl)-piperazin-1-yl]-cyclohexylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(3-cyclopropylmethoxy-pyridin-2-yl)-piperazin-1-yl]-cyclohexylamine(910606-15-4)
• EPA Substance Registry System: 4-[4-(3-cyclopropylmethoxy-pyridin-2-yl)-piperazin-1-yl]-cyclohexylamine(910606-15-4)

Safety Data

• Hazardous Substances Data: 910606-15-4(Hazardous Substances Data)

Upstream product

• 179321-49-4 N-(tert-butoxycarbonyl)-4-aminocyclohexanone 
• 910606-13-2 1-(3-cyclopropylmethoxy-pyridin-2-yl)-piperazine 

Relevant articles and documents

(Arylpiperazinyl)cyclohexylsufonamides: Discovery of α1a/1d-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS)

Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS) can be effectively treated by α1-adrenergic receptor antagonists. Unfortunately, all currently marketed α1 blockers produced CV related side effects that are caused by the subtype non-selective nature of the drugs. To overcome this problem, it was postulated that a α1a/1d subtype selective antagonist would bring more benefit for the treatment of BPH/LUTS. In developing selective α1a/1d ligands, (arylpiperazinyl)cyclohexylsulfonamides were synthesized and their binding profiles against three cloned human α1-adrenergic receptor subtypes were evaluated. Many compounds show equal affinity for both α1a and α1d subtypes with good selectivity against the α1b subtype. They also overcome the problem of dopamine receptor affinity that previous analogues had exhibited.