910606-91-6Relevant academic research and scientific papers
Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure-activity relationships of a peptide scaffold
Yue, Eddy W.,Wayland, Brian,Douty, Brent,Crawley, Matthew L.,McLaughlin, Erin,Takvorian, Amy,Wasserman, Zelda,Bower, Michael J.,Wei, Min,Li, Yanlong,Ala, Paul J.,Gonneville, Lucie,Wynn, Richard,Burn, Timothy C.,Liu, Phillip C.C.,Combs, Andrew P.
, p. 5833 - 5849 (2007/10/03)
The structure-based design and discovery of the isothiazolidinone (IZD) heterocycle as a mimic of phosphotyrosine (pTyr) has led to the identification of novel IZD-containing inhibitors of protein tyrosine phosphatase 1B (PTP1B). The structure-activity re
