91064-04-9Relevant academic research and scientific papers
Design, synthesis and antifungal activity of psoralen derivatives
Yu, Xiang,Wen, Ya,Liang, Chao-Gen,Liu, Jia,Ding, Yu-Bin,Zhang, Wei-Hua
, (2017/11/07)
A series of linear furanocoumarins with different substituents have been designed and synthesized. Their structures were confirmed by 1H-NMR spectroscopy, high resolution mass spectra (EI-MS), IR, and X-ray single-crystal diffraction. All of the target compounds were evaluated in vitro for their antifungal activity against Rhizoctorzia solani, Botrytis cinerea, Alternaria solani, Gibberella zeae, Cucumber anthrax, and Alternaria leaf spot at 100 μg/mL, and some of the designed compounds exhibited potential antifungal activities. Compound 3a (67.9%) exhibited higher activity than the control Osthole (66.1%) against Botrytis cinerea. Furthermore, compound 4b (62.4%) represented equivalent antifungal activity as Osthole (69.5%) against Rhizoctonia solani. The structure-activity relationship (SAR) study demonstrates that linear furanocoumarin moiety has an important effect on the antifungal activity, promoting the idea of the coumarin ring as a framework that might be exploited in the future.
Synthesis and α-glucosidase inhibitory, DPPH scavenging activity of substituted 2-oxo-2H-chromen-7-yl-dihydrogen phosphate derivatives
Kumar, J. Ashok,Tiwari, Ashok K.,Ali, A.Zehra,Rao, R. Ranga,Raju, B. China
experimental part, p. 1251 - 1257 (2012/01/12)
Series of phosphorylated coumarin derivatives (4a-j) were synthesized by Pechmann condensation, phosphorylation, and debenzylation reactions in very good yields. Thus, synthesized compounds (4a-j) were evaluated for their α-glucosidase and 1,1-diphenyl-2-picrylhydrazyl scavenging activities; few compounds showed moderate to good activity. J. Heterocyclic Chem., 00, 00 (2011). Copyright
Synthesis and bioactivity of novel coumarin derivatives containing (E)-methyl 2-(methoxyimino)-2-phenylacetates
Guan, Ai Ying,Liu, Chang Ling,Li, Zhi Nian,Zhang, Ming Xing
scheme or table, p. 663 - 666 (2012/01/13)
Ten coumarin derivatives containing (E)-methyl 2-(methoxyimino)-2- phenylacetate were synthesized and bioassayed. The compounds were identified by IR, 1H NMR and elemental analyses. The test results indicated that compound 5j (R1 is methyl and R2 is n-C6H 13) was the optimal structure in this paper with good fungicidal activity against CDM (85%) at 6.25 mg/L concentration.
