91065-80-4Relevant academic research and scientific papers
Novel benzopyranyl tetracycle compound and pharmaceutical composition having excellent anti-inflammatory effect comprising the same
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Paragraph 0064-0067; 0069, (2019/09/05)
The present invention relates to a novel compound of chemical formula 3 or 5 and a pharmaceutical composition having an excellent anti-inflammatory effect comprising the same. The compounds inhibit the migration of HMGB1 protein, which is an inflammation-inducing factor, from nucleus to cytoplasm, thereby having an excellent inflammation-inhibiting effect, particularly having an excellent effect of treating or preventing septicemia and the like.COPYRIGHT KIPO 2019
Benzopyranyl tetracycle compound and pharmaceutical composition having excellent anti-inflammatory effect comprising the same
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Page/Page column 10, (2019/01/07)
The present invention relates a novel compound represented by the following Formula 3 or Formula 5, and a pharmaceutical composition having superior anti-inflammatory effect comprising the above. The above compound inhibits the translocation of HMGB1 form nucleus to cytosol, and then has remarkable effect of treating or preventing inflammatory disease, especially sepsis.
Discovery of novel benzopyranyl tetracycles that act as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand
Zhu, Mingyan,Kim, Myung Hee,Lee, Sanghee,Bae, Su Jung,Kim, Seong Hwan,Park, Seung Bum
supporting information; experimental part, p. 8760 - 8764 (2011/02/23)
A novel benzopyran-fused molecular framework 7ai was discovered as a specific inhibitor of RANKL-induced osteoclastogenesis using a cell-based TRAP activity assay from drug-like small-molecule libraries constructed by diversity-oriented synthesis. Its inhibitory activity was confirmed by in vitro evaluations including specific inhibition of RANKL-induced ERK phosphorylation and NF-κB transcriptional activation. 7ai can serve as a specific small-molecule modulator for mechanistic studies of RANKL-induced osteoclast differentiation as well as a potential lead for the development of antiresorptive drugs.
An expedient protocol for conversion of olefins to α-bromo/iodoketones using IBX and NBS/NIS
Moorthy, Jarugu Narasimha,Senapati, Kalyan,Singhal, Nidhi
experimental part, p. 2493 - 2496 (2009/08/17)
A variety of olefins have been shown to undergo conversion to the corresponding α-bromo/iodoketones when reacted with NBS/NIS and IBX in DMSO at room temperature. While the reaction is found to occur rapidly with e-rich arylolefins leading to the corresponding haloketones in 65-95% yields in 0.3-3.0 h, those containing e-withdrawing groups are found to yield diketones concomitantly, such that the latter are the exclusive products over extended duration of the reactions.
Base-induced coupling of α-azido ketones with aldehydes -an easy and efficient route to trifunctionalized synthons 2-azido-3-hydroxy ketones, 2-acylaziridines, and 2-acylspiroaziridines
Patonay, Tamas,Juhasz-Toth, Eva,Benyei, Attila
, p. 285 - 295 (2007/10/03)
An improved synthesis of a-azido ketones under phase-transfer conditions has been developed. The transformation of α-azido ketones into acyclic and heterocyclic 2-azido-3-hydroxy ketones has been demonstrated and the relative configurations of the chroman
