910656-27-8

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one is used as a potential pharmaceutical agent for its possible biological activity. The presence of various functional groups suggests that it may have applications in the development of new drugs or therapeutic agents.
Used in Research and Development:
In the field of chemical research and development, 4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one serves as a subject for further investigation. Its complex structure and potential biological activity make it an interesting candidate for studies aimed at understanding its properties and exploring its potential uses in various applications.

Upstream product

• 910656-32-5 4-(4-fluorophenyl)-2-oxo-2H-chromene-7-carboxaldehyde 
• 1222175-45-2 (2S)-2-(5-amino-1,3,4-oxadiazol-2-yl)-1,1,1-trifluorobutan-2-ol 
• 1229617-81-5 C₂₂H₁₉F₄N₃O₄S 

Downstream Products

• 1137737-87-1 (1S)-N-([4-(4-fluorophenyl)-2-oxo-2H-chromen-7-yl]methyl)-5-[1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-aminium4-methylbenzenesulfonate 
• 1137737-86-0 (S)-4-(4-fluorophenyl)-7-[({5-[1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl}amino)-methyl]-2H-chromen-2-one benzenesulfonate 

Relevant academic research and scientific papers

A practical synthesis of 5-lipoxygenase inhibitor MK-0633

Practical, chromatography-free syntheses of 5-lipoxygenase inhibitor MK-0633 p-toluenesulfonate (1) are described. The first route used an asymmetric zincate addition to ethyl 2,2,2-trifluoropyruvate followed by 1,3,4-oxadiazole formation and reductive amination as key steps. An improved second route features an inexpensive diastereomeric salt resolution of vinyl hydroxy-acid 22 followed by a robust end-game featuring a through-process hydrazide acylation/1,3,4-oxadiazole ring closure/salt formation sequence to afford MK-0633 p-toluenesulfonate (1).

The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor

The discovery of novel and selective inhibitors of human 5-lipoxygenase (5-LO) is described. These compounds are potent, orally bioavailable, and active at inhibiting leukotriene biosynthesis in vivo in a dog PK/PD model. A major focus of the optimization

THIADIAZOLE SUBSTITUTED COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITOR

The instant invention provides compounds of Formula (Ia) which are leukotriene biosynthesis inhibitors, wherein X is O or S, Y is O, S, -NR6-CHR7- or -NR8-C(O)- and A is selected from 5-membered aromatic heterocyclic ring, 6-membered aromatic heterocyclic ring, naphthelenic or heterobicyclic aromatic ring system, phenyl and benzyl. A is optionally mono- or disubstituted. Compounds of Formula (Ia) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.